FeedCity

How high-content screening and Thermo Fisher EVOS automated microscopes are turning cellular senescence imaging into a quantitative engine for anti-ageing drug discovery.

CMLase is an engineered enzyme that reverses CML advanced glycation end-products on long-lived human proteins. What the July 2026 Nature Communications paper showed — and what it might mean for longevity.

Evidence-based UK review of alpha-lipoic acid for longevity, sleep, and healthy ageing. Updated 2026-09-04.

Evidence-based UK review of carnosine for longevity, sleep, and healthy ageing. Updated 2026-09-04.

Evidence-based UK review of resveratrol for longevity, sleep, and healthy ageing. Updated 2026-09-04.

Evidence-based UK review of moringa for longevity, sleep, and healthy ageing. Updated 2026-09-04.

Evidence-based UK review of saffron for longevity, sleep, and healthy ageing. Updated 2026-09-04.

Evidence-based UK review of NAC for longevity, sleep, and healthy ageing. Updated 2026-09-04.

Evidence-based UK review of spermidine for longevity, sleep, and healthy ageing. Updated 2026-09-04.

Evidence-based UK review of quercetin for longevity, sleep, and healthy ageing. Updated 2026-09-04.

Evidence-based UK review of taurine for longevity, sleep, and healthy ageing. Updated 2026-09-04.

Yamanaka factors OSKM can reset cellular age. Learn how partial reprogramming works, what mouse studies show, and why the first human trial of ER-100 matters.

The longest-living organism on Earth is a fungus. Explore what Armillaria ostoyae reveals about mycelial longevity and which fungal proteins and supplements are being studied for healthy ageing.

Every developer has a ~/dev/tools/scripts folder. Mine has run for years without an index. I asked Claude Code to read every file in it and write one.

The brief was simple: read the whole directory, then produce an INDEX.md with three columns — tool, how to run it, what it does.

It scanned roughly 40 files: Python CLIs built on uv, shell wrappers, one-off Snowflake key-rotation scripts, a tmux session launcher, a Hacker News summarizer. Some had docstrings. Several had none, and their purpose was recoverable only by reading the argparse block or the hardcoded constants at the top.

Most developers have a graveyard of dotfiles, .env files, and Slack DMs containing tokens that were supposed to be temporary. This post describes the pattern I use to keep all local dev secrets in a password manager and inject them into my shell on demand — nothing sensitive ever touches disk.

The full setup lives in my dot-local repo on GitHub, including the helper functions and new-machine setup guide.

The Problem

I work across multiple machines: a work Mac that uses 1Password and a personal Mac that uses Bitwarden. I needed a single pattern that worked on both without maintaining two separate codebases or hardcoding tool-specific logic everywhere.

I saw this post (via Dave Winer) about issues with the ability of feed readers to read feeds from websites hosted by or using Cloudflare. I ran into this problem in trying to access feeds from the Seattle Times website (eventually had to use Playwright to act as a web browser to download the files). […]

Anker beat Apple to its home hub with MindBase. www.macrumors.com/2026/09/0…

Checking out my LLM models on local server - still has not gone rogue. Wondering when they will break containment.

this event is organised by smallweb.dreamwidth.org for which i have registered. (they forced me to create a LiveJournal thingy that i don't even want!) anyway, i'll primarily be posting my notes here.