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Scientists have uncovered why two seemingly opposite ways of targeting the same brain receptor can both promote weight loss. In mice, activating the GIP receptor in the brainstem reduced appetite, while blocking it in the hypothalamus removed a kind of “brake” on fullness signals. The discovery helps explain why very different obesity drugs can achieve similar results and suggests that carefully combining GIP-targeting treatments with GLP-1 drugs like those related to Wegovy and Ozempic could produce stronger effects.

Greed, 1560 #pieterbruegel #bruegel

“President Donald Trump has finally given the green light to pour millions of dollars from his personal PAC toward boosting vulnerable Republicans in November, as some top campaign advisers privately acknowledge that Republicans’ chances of keeping control of both the House and Senate are dwindling,” CNN reports. “Trump’s political team is still debating what the […]

“Keeping gas prices low is now the United States’ ‘goal No. 1’ in the Iran war, Vice President JD Vance has said, as Washington threatened an indefinite naval blockade and signaled it would soon intensify economic pressure on Tehran,” NBC News reports. “The comments appeared to be the latest shift in the public rationale for […]

“Democrats trying to unseat Republican senators in deep-red states have pursued a new strategy this year: dropping out,” the Washington Post reports. ”The Democratic Senate nominees in Nebraska, Idaho and South Dakota — all heavily Republican states — withdrew from the ballot after their primaries, clearing the field for independent candidates. Some Democrats hope that […]

What tax history teaches us about this dire moment

“President Donald Trump plans to affix gold-colored presidential seals to the outside of his White House ballroom, breaking with the restrained aesthetic of the executive mansion, according to renderings that the administration shared publicly Friday,” the Washington Post reports. ”The Trump administration included the renderings as part of an emergency request to the Supreme Court, […]

Wall Street Journal: “As the mood of the nation sours on Silicon Valley’s vision for the future, Flock cameras and data centers have become personae non grata in several communities. In many ways, they are physical manifestations of artificial intelligence—an incorporeal technology—that’s fueling both big dreams and new nightmares.” “On Thursday, amid mounting public pressure, […]

“Senior Trump administration officials have doubled down on economic pressure in the fight with Iran, making lower oil prices a top war aim and vowing unprecedented financial sanctions that would force Tehran to reopen the Strait of Hormuz,” the Wall Street Journal reports. “Iran late Thursday attacked two United Arab Emirates ships in the strait, […]

“A week of stifling heat in Europe this June was unusually deadly, mortality data shows, producing a historic spike in deaths in a continent where major heat waves are becoming more common,” the New York Times reports. “Around 16,000 more people than usual died in Europe during the heat wave, according to an analysis by […]

“The U.S. attorney’s office in Chicago has spent the past year investigating a Democratic fund-raising firm once co-owned by the daughter of the judge in President Trump’s hush-money trial in New York,” the New York Times reports.

New York Times: “He is trying to pull off a difficult political comeback — a quick return to the Senate, where he served three terms before losing his seat in 2024, amid shifting partisan preferences in his state and a tsunami of spending by the cryptocurrency industry to oust him.” “This time, he is hoping […]

“Dr. Anthony Fauci on Friday declined a request to appear voluntarily before a second Senate panel after majority Republicans on the Homeland Security Committee voted along partisan lines last week to hold the longtime infectious disease expert in contempt,” the Associated Press reports.

Mice can access memories after hibernation, a state that largely shuts their brains off and reduces synapses, suggesting that memories are stored across shifting neural systems.