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An experimental GLP-1 pill helped people with obesity or overweight lose as much as 12.1% of their body weight in just 36 weeks. Unlike injectable drugs such as Wegovy and Ozempic, aleniglipron is a small molecule that can be taken once daily with or without food and could potentially be produced more easily at scale.

Silver nanocatalysts have been found to switch where they perform their most important reactions depending on whether a solid oxide cell is making electricity or hydrogen. The discovery could enable smarter catalyst designs that boost clean power generation while making green hydrogen more energy-efficient.

A total solar eclipse will plunge parts of Europe into darkness on August 12, 2026, with Spain offering some of the best views. ESA will livestream the spectacle from the Javalambre Observatory, combining telescope feeds, drone footage, and expert commentary. At 20:31 CEST, the observatory will experience 1 minute and 21 seconds of totality, revealing the Sun’s normally hidden outer atmosphere.

NASA engineers have found a clever way to squeeze more life out of Voyager 2, nearly half a century after it left Earth. In an operation nicknamed the “Big Bang,” the team simultaneously shut down certain power-hungry hardware and switched to lower-power alternatives while keeping the spacecraft warm enough to survive.

Dogs have been shaping—and being shaped by—humans for about 15,000 years, evolving from early partners of hunter-gatherers into an astonishing range of specialized companions. Across the globe, they adapted alongside people to wildly different environments and needs, from powerful Arctic sled dogs and agile rainforest hunters to high-altitude dogs with genetic traits for surviving thin air. Some were even bred for wool, while others played important spiritual or ceremonial roles.

Very high levels of the inherited cholesterol-related particle Lp(a) were linked to a greater risk of major cardiovascular events, particularly stroke and cardiovascular death, in a study of more than 20,000 people. Since elevated Lp(a) often flies completely under the radar, a simple blood test could uncover hidden heart risk that standard cholesterol testing may miss.

The rise of the potato in the Andes appears to have left a lasting mark on human DNA. Indigenous Peruvians carry exceptionally high numbers of a starch-digestion gene, likely because people with more copies gained an evolutionary advantage once potatoes became a staple food. The change began thousands of years before European contact, providing unusually strong evidence that diet can shape human evolution.

A daily glass of 100% fruit juice or a smoothie may help improve more than just fruit intake. In a small four-week trial, participants who added one to a healthier diet showed significantly lower depression scores, hinting that a simple dietary change could also support mental well-being.

Just a couple of hours of strength training each week could have surprisingly powerful effects on longevity. People who lifted weights for around 90 to 120 minutes weekly had a 13% lower risk of dying early, with especially large reductions in deaths from cardiovascular and neurological diseases. Pairing strength training with regular aerobic exercise was even more impressive, lowering overall death risk by about 45%.

A 240-million-year-old reptile discovered in Brazil is revealing what evolution looked like just before the rise of dinosaurs and crocodiles. The small predator had unusually positioned legs that may have allowed it to move more efficiently than many earlier reptiles. Its close relatives were previously known mostly from other continents, suggesting these ancient animals spread much farther across the Triassic world than scientists realized.

Cassini data has revealed a surprising twist in Saturn’s magnetic shield: the planet’s rapid rotation appears to drag a key opening in its magnetosphere far toward the afternoon side instead of keeping it near noon, as happens on Earth. The finding confirms that giant planets like Saturn operate under a fundamentally different magnetic regime, where fast spin and charged material from moons such as Enceladus can overpower the Sun’s influence.

The solar-powered limited edition may be here to mark the final Dutch Grand Prix taking place in Zandvoort, but it's the juicy iconic colorway WIRED's been waiting for.

“We are only semi-negotiating with them.” — President Trump, quoted by Axios, no ceasefire negotiations with Iran.

“Pete Hegseth has become the least popular member of President Donald Trump’s cabinet,” Mediaite reports. “According to polling data from Quinnipiac and Fox News, Hegseth’s net approval rating was a staggering -22. Trailing behind Hegseth were Vice President JD Vance (-17), Health and Human Services Secretary Robert F. Kennedy Jr. (-9), and Secretary of State […]

The Bureaucratic Hellscape of Trump Authoritarianism This morning I want to focus your attention on another especially Kafkaesque example of...

Check them out Hackernoon today: Cyber Libertarians: Esther Dyson & The Knowledge Age. Esther is an old friend and one of my favorite people. Front burner for her right now is .agent. Exit signals Last night we were suffering through one of the most annoying movies we've ever seen (Ladies First on Netflix, which, among other […]

Something shocking happened. Trump finally admitted the contractor was at fault for the Reflecting Pool.

The 2 largest private prison companies in the U.S. have reported $1.4 billion in quarterly revenue as the number of people in immigration detention reaches record levels.

7 people have died after being infected with Vibrio vulnificus, a flesh-eating bacteria that contaminates water and seafood. The Trump administration cut mandatory public health reporting of Vibrio vulnificus last year.

Taylor Farms has recalled multiple products containing jalapeños after a multi-state salmonella outbreak. This comes after the Trump administration fired FDA staff who helped conduct food safety inspections.