A vitamin D analog may help break down pancreatic cancer’s protective defenses, potentially making tumors more vulnerable to chemotherapy and immune attack. A small clinical trial found encouraging responses, especially in patients whose tumors had high levels of the vitamin D receptor.

Scientists have identified an enzyme that may act as a natural defense against the worsening of fatty liver disease, which affects an estimated 100 million Americans. The enzyme, called UBE2N, helps liver cells clear away damaged mitochondria and break down fat, potentially preventing the inflammation, scarring, and cell damage associated with the more dangerous condition MASH.

ESA’s Juice spacecraft raced past Earth on September 28, using our planet’s gravity to dramatically reshape its path toward Jupiter without burning much fuel. The flyby changed its direction by 20 degrees and increased its speed by 3.5 km/s, while also giving scientists a rare chance to test its instruments on Earth and the Moon.

Scientists studying Chang’e-6 lunar soil have discovered a previously unknown magnetic mineral in natural Moon samples: a form of metallic iron called γ-Fe. Found inside tiny impact-glass particles, the nanoscale iron can preserve a stable magnetic signal, potentially acting like a microscopic fossil of the Moon’s long-lost magnetic field.

Ultra-detailed simulations are showing how the first stars lit up the dark Universe and seeded space with elements such as carbon, oxygen, and iron. The MEGATRON project could bridge JWST observations of the earliest galaxies with chemical clues preserved in ancient stars today.

NASA’s Roman Space Telescope has demonstrated remarkable pointing stability and given its powerful planet-imaging coronagraph its first look at the cosmos. The telescope can already stay locked on a target with precision comparable to aiming a laser at a dime from about 150 miles away. Its coronagraph also captured stars in the Large Magellanic Cloud, confirming that the instrument can produce focused images.

Researchers say stress on Southern California’s San Andreas and San Jacinto faults has reached some of the highest levels seen in a 1,000-year simulation. Because both faults are highly stressed at the same time, the Cajon Pass junction may be increasingly primed for a rupture that could cross both systems, although the study does not predict when an earthquake will happen.

The essential amino acid leucine can boost cellular energy production by protecting key proteins on mitochondria from being destroyed. The discovery reveals a new connection between nutrition and metabolism that could eventually lead to new approaches for metabolic disorders and cancer.

Scientists have linked a gut bacterial compound called ImP to greater Alzheimer’s risk, harmful brain protein buildup, and faster cognitive decline. The finding raises the possibility that reducing ImP in the blood could one day help slow or prevent dementia.

Researchers have demonstrated that quantum fluctuations in supposedly empty space can strengthen superconductivity, raising the transition temperature of an ultrathin material by as much as 5.4%. The discovery opens the possibility of using specially engineered vacuum environments to control quantum materials without direct contact or external driving.

Vitamin C may do more than support the immune system. In a phase 2 trial of people with precancerous or low risk blood cancers, daily vitamin C did not slow abnormal cell growth, but it was linked to favorable changes in inflammation and fewer serious complications. An exploratory follow up also found fewer deaths among participants taking vitamin C than among those receiving placebo.

Ultrashort electrical pulses allowed scientists to push superconductors closer than ever to the point where their electron pairs actually break apart. The method revealed hidden differences between superconducting materials and could open new ways to probe and control their quantum behavior.

Nearly 6 in 10 people with high blood pressure in a large England study had never been diagnosed or treated, and half of those already taking medication still had elevated readings. Researchers say a more proactive approach to finding and controlling hypertension could prevent thousands of heart attacks and strokes.

JWST has revealed that galaxies were spreading carbon, oxygen, and other heavy elements through space just 500 million years after the Big Bang. The surprising discovery suggests the young universe became chemically enriched much earlier than expected, potentially erasing traces of its very first stars.

Mysterious 97-million-year-old magnetic fossils may be the oldest evidence of an animal using Earth’s magnetic field like a built-in GPS. Their sophisticated magnetic structure could have helped an unknown ocean creature navigate thousands of kilometers with surprising precision.

Weak sunlight can still damage skin DNA if you spend enough time outdoors, according to a landmark Australian study. Even UV doses too low to cause visible redness triggered cellular damage that could accumulate over time and contribute to skin cancer risk.

High-risk MDS stem cells appear to have an unexpected “energy addiction,” relying far more heavily than healthy blood-forming cells on a molecule called NAD. Disrupting this energy pathway selectively weakened the cancer-driving cells, revealing a potential new target for treatment.

Strength training may be one of the most powerful tools for staying independent as you age. Age related muscle loss, known as sarcopenia, can make everyday tasks harder while increasing the risk of falls, fractures, and loss of mobility. Research shows that resistance exercises such as squats, weights, resistance bands, and even body weight movements can preserve or rebuild strength, and surprisingly, even one session a week can produce meaningful benefits.

Scientists at the University of Chicago have uncovered a surprising quantum state in the layered magnetic material Fe5GeTe2, where huge numbers of electrons move together unusually slowly while remaining quantum coherent. The behavior contradicts existing theoretical predictions about how the material’s magnetism should work and suggests scientists may need to rethink its underlying physics.

Scientists may have found a clue to one of the biggest mysteries surrounding the origin of life: how fragile RNA molecules could gather and survive before cells existed. New research shows that RNA is unusually good at assembling into tiny liquid-like droplets that concentrate molecules and can harden into protective, gel-like structures. Remarkably, much of this behavior may come down to a single oxygen-containing chemical group that RNA has but DNA lacks.

Scientists found that five seemingly unrelated conditions, including long Covid, ME/CFS, and PTSD, may disrupt many of the same biological networks involved in immunity, metabolism, and cellular energy. The findings could help explain their shared symptoms and may open the door to new blood tests and treatments.

People who followed the MIND diet more closely showed slower brain shrinkage and less grey matter loss over time, with the strongest differences equivalent to about 2.5 years of delayed brain aging. Berries and poultry were linked with healthier brain changes, while sweets and fried fast foods were associated with greater tissue loss.

The Alzheimer’s risk gene APOE4 may actively damage brain blood vessels and sabotage the cellular systems that remove harmful proteins. Researchers were able to reverse some of these effects in experiments, revealing promising new targets for Alzheimer’s, Parkinson’s, and other neurodegenerative diseases.

People with depression who dramatically cut ultra-processed foods experienced notable improvements in their symptoms in a small preliminary study. Researchers suspect healthier eating may benefit the brain partly by reducing gut damage and chronic inflammation.

Scientists have identified two new species of large Australian stick insects, including one that lays extraordinary “lidded” eggs never before recorded in the group. The discovery also revealed that a familiar stick insect had been misidentified for decades, showing how much biodiversity may still be hiding in plain sight.

A proposed qubit made with superfluid helium could cut quantum computing error rates by around 100 times by shielding quantum information from common forms of electromagnetic noise. If experiments confirm the predictions, the technology could eventually work alongside today’s superconducting qubits or serve as a new kind of quantum memory.

A new protective fabric boosted strawberry yields by as much as 3.56 times while blocking insects and still allowing sunlight, rain, and airflow to reach the plants. Originally inspired by research on military clothing, Plant Armor could also help farms reduce pesticide and water use.

More than half of 16,000 apparently healthy adults had signs of atherosclerosis, with arterial plaques already detectable in about 1 in 13 people ages 18 to 29. Researchers say directly imaging the arteries could reveal hidden cardiovascular disease years or even decades before symptoms appear.

UCLA researchers built an AI system that uses light to analyze more than a dozen videos simultaneously, detecting deepfakes with nearly 98% accuracy. Its speed, low energy demands, and resistance to attacks could make it a powerful tool for screening the growing flood of AI-generated video.

A common mistake during blood pressure checks could make readings appear substantially higher than they really are. Johns Hopkins researchers found that leaving the arm unsupported can raise systolic readings by about 6.5 mmHg, potentially affecting a hypertension diagnosis.