Researchers have found a way to slash the processing time for 3D-printed zirconia crowns from as much as 100 hours to under 30 minutes. The advance could eventually let dentists print strong, customized permanent crowns for patients within a single appointment.

A massive analysis involving more than 100 million people has found strong links between recreational drug use and stroke, including among younger adults. Cocaine was associated with nearly double the risk of stroke, amphetamines with more than double the risk, and cannabis with a 37% increase.

An abandoned farm field became a flourishing wildflower meadow within little more than a decade, with plant diversity doubling and thousands of orchids appearing naturally. The discovery suggests that simply giving nature time to recover could be a powerful and inexpensive tool for restoring biodiversity.

Researchers at CERN have created microscopic versions of the early Universe by colliding surprisingly small atomic nuclei at nearly the speed of light. The collisions produced quark-gluon plasma, the ultra-hot matter believed to have filled the cosmos shortly after the Big Bang. Even more intriguingly, the particles left behind reveal the shape of the nuclei that created them, offering a new way to probe both nuclear physics and the Universe’s earliest moments.

Older adults with mild cognitive impairment and sleep problems who took at least 5,000 IU of vitamin D daily scored more than 13% higher on a cognitive test than those taking none. The preliminary findings suggest vitamin D could be worth studying as a potentially modifiable factor during an early window of cognitive decline.

Researchers have uncovered a possible reason why the Alzheimer’s risk gene APOE4 can disrupt the brain long before memory problems begin. In mice, APOE4 increased a protein called Nell2, shrinking neurons and making memory circuits unusually active. That early hyperactivity predicted worse memory later in life. Reducing Nell2 in adult mice reversed the abnormal changes, raising hopes for a new way to intervene before Alzheimer’s progresses.

Mice that developed compulsive drinking after alcohol abstinence showed more than double the activity in a brain region associated with stress and addiction. Because the signal appeared before they drank again, researchers think it could eventually help predict who is most at risk of relapse.

Astronomers have found stars that repeatedly skim past supermassive black holes, surviving each encounter while producing a new burst of light. In some systems, those flares mysteriously fade with every return. Researchers now think the key may be stars that were already spinning extremely fast before being captured. That rapid rotation could explain both the fading flares and how the stars ended up in such extraordinarily tight black hole orbits.

Greenland sharks may live for 400 years without suffering the kind of retinal decline normally associated with aging. Researchers found healthy eye tissue and active proteins specially adapted for seeing blue light in the dim Arctic depths. DNA repair mechanisms may help keep their eyes functioning across centuries. The discovery could eventually offer new clues for protecting human vision as we age.

Astronomers using JWST have discovered that massive early galaxies contain far more small, faint stars than expected. That hidden population could make some of these galaxies three to four times more massive than previous estimates. The finding makes it even harder to explain how enormous, mature galaxies formed so soon after the Big Bang. It could also suggest that planets around low-mass stars were more common in the early universe than scientists realized.

Exercise may not be a powerful weight-loss tool on its own, but it appears to play a much bigger role in preventing lost weight from returning. By preserving muscle, supporting metabolism, improving fat burning, and regulating appetite and blood sugar, regular activity can make long-term weight maintenance easier.

Peppermint oil may have an unexpected benefit for people with mildly high blood pressure. Adults who took a small dose twice daily for 20 days saw their systolic blood pressure fall by an average of 8.5 mmHg, while a placebo group showed little change. Researchers say the inexpensive oil could eventually provide a simple additional option for managing elevated blood pressure.

A simple yeast-based food supplement may help restore the immune system’s ability to fight cancer, according to new research in mice. Scientists found that yeast beta-glucan reprogrammed early immune cells in the bone marrow, leading to stronger, longer-lasting cancer-fighting responses against colorectal, skin, and breast cancer cells.

Freezing the liquid core of an optical fiber produced an extreme environment where light and sound interact more than 1,000 times more strongly than in ordinary fibers. Researchers used the effect to create optoacoustic memory, potentially paving the way for lower-energy photonic computers and advanced quantum technologies.

People who speak several languages may have brains that age more slowly, with four-language speakers showing brains that appeared about 13 years younger than those of monolinguals. Starting earlier and becoming highly fluent were also linked to a stronger effect.

Honeybee queens exposed to pesticides can shift some of the contamination into their eggs, revealing a previously unknown survival strategy. The process may protect the queen while putting developing offspring, and potentially the entire colony, at risk.

Pancreatic cancer patients with at least 21 natural teeth survived nearly two years longer after surgery than those with fewer teeth in a study of 339 people. Researchers suspect tooth loss may reflect decades of inflammation, frailty, nutrition, and other factors tied to the body’s overall resilience.

Scientists have linked a specific gut bacterium, Roseburia inulinivorans, to stronger muscles in both humans and mice. Older adults who carried it had 29% greater handgrip strength, while treated mice gained about 30% more grip strength and developed larger, more fast-twitch muscle fibers. The bacterium was also less common in older people. Researchers say it could eventually become a probiotic candidate for helping combat age-related muscle loss.

A tiny, fully intact Indigenous pot buried for roughly 400 years has left archaeologists wondering why such a usable object was deliberately abandoned. Found at a historic Potano-Timucua village in Florida, the mysterious vessel is helping reveal a complex world of Native traditions, Spanish influence, trade, and migration.

A few minutes of sprinting may reshape the bloodstream far more dramatically than a much longer moderate workout. Six 30-second sprints altered nearly a quarter of the blood proteins measured and more than 200 metabolites, while 90 minutes of moderate cycling produced far smaller immediate changes. Many of the proteins affected by sprinting were also associated with lower risks of obesity, type 2 diabetes, and other metabolic diseases.

Scientists analyzing a 2,200-year-old Roman shipwreck found that its hull was coated with pine tar and, in one area, a mixture of tar and beeswax. Pollen trapped in those ancient coatings acted like a geographic fingerprint, revealing the landscapes surrounding the ship when repairs were made.

Scientists watched a light-triggered hidden state form inside a material in only 30 femtoseconds, revealing a step that had never been seen before. The material first entered a fleeting electronic state in which its bonds reorganized in a repeating pattern, followed by tiny atomic shifts. This ultrafast pathway could offer a new way to control electronic properties with light and help inspire faster, more responsive technologies.

A hormone already known for curbing appetite and supporting weight loss may have a surprising second job: protecting the liver from inflammation and scarring. Researchers at McMaster University found that GDF15 activates a previously unknown brain-to-liver pathway that triggers the release of glucocorticoids, helping calm immune activity in the liver.

For decades, scientists have puzzled over why certain atomic nuclei unexpectedly produce large numbers of low-energy gamma rays. A new experiment traced the effect to magnetic changes inside the nucleus, where protons and neutrons effectively flip their tiny internal magnets. The discovery could sharpen models of everything from nuclear reactions on Earth to the creation of heavy elements in stars and neutron star mergers.

Two very different types of quantum particles may be able to form stable droplets that hold themselves together, challenging decades of conventional thinking. The prediction could soon be tested experimentally and may reveal an unexpectedly rich world of new quantum phases.

AI may be able to predict how strongly someone will respond to a vaccine before they receive it. By analyzing antibody patterns in more than 4,000 people, researchers found signs of “immune readiness” that helped distinguish strong responders from weak ones. Surprisingly, even some healthy people responded poorly, while some immunosuppressed people mounted strong responses.

People who participated in colorectal cancer screening had a 43% lower risk of dying from the disease, according to long-term data from more than 376,000 people in Sweden. The findings suggest that completing a simple at-home screening test could make a major difference in survival.

A colossal cliff system created as the supercontinent Rodinia broke apart may have exposed the heart of the Grand Canyon nearly a billion years before the Colorado River carved it. The ancient landscape could also help explain why enormous sections of North America’s geological record appear to be missing.

Scientists have identified exceptionally rare soft tissue preserved in a 450-million-year-old crinoid fossil, more than 200 million years older than the first dinosaurs. Its delicate tube feet offer a remarkable new window into how some of Earth’s earliest reef animals lived, fed, and evolved.

A compound made when gut bacteria break down dietary fiber may do more than briefly calm inflammation—it could leave a lasting protective “memory” in the gut. Northwestern Medicine researchers found that butyrate can reprogram intestinal lining cells so they continue encouraging anti-inflammatory immune responses even after the compound is gone. In mice, this effect boosted production of the immune-calming molecule IL-10 and reduced the severity of colitis-like disease.